Patellofemoral joint complication is among the leading causes for the failure of primary total knee replacement. In the knee joint, the anterior part of the femur is called the trochlear groove (Figure 1). When the joint wears down and a total knee replacement surgery is recommended, one of the goals of the femoral component is to restore the trochlear groove in such a way that the patella follows its natural pathway during knee movement. Most orthopedic device manufacturers address this goal with one of two design philosophies: ‘neutral trochlear groove’, or ‘lateralized groove’ (Figure 2). We (Exactech) performed a study to understand the native, healthy trochlear groove and compare its characteristics to those of implants from both design philosophies. To achieve our study goal, we recognized that a large study population would be needed in order to form a representative sample, as well as an efficient way to analyze the trochlear groove on each of the bones in the population.