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INTERVIEW

Mimics Innovation Finalist 2021: Nicholas A. Szugye

2 min read

A Novel Method of Donor-Recipient Size Matching in Pediatric Heart Transplantation: A Total Cardiac Volume Predictive Model

What was the dream?

To create a predictive model that accurately assesses size matching in pediatric heart transplantation by measuring donor total cardiac volume (TCV), based on anthropometric and chest X-ray cardiac measurements.

What was the challenge?

The pediatric heart transplant community uses weight-based donor-to-recipient size matching almost exclusively, despite no evidence to validate weight as a reliable surrogate of cardiac size. Donor size mismatch is the second most common reason for the refusal of donor hearts in current practice (>30% of all refusals).

N. Szugye and their team sought to establish a predictive model for donor TCV on the basis of anthropomorphic and chest X-ray (CXR) cardiac measures.

What were the results?

Szugye’s predictive model that takes into account weight, height, sex, age, AND a 1-view anteroposterior chest X-ray proves to be a reliable and consistent method to improve size matching. Therefore, TCV can be accurately predicted from readily available anthropometrics and CXR heart width. This simple method of TCV estimation can provide a reliable and consistent method to assess donor TCV. In future studies, TCV-based size matching can be used to set more accurate donor size criteria and assess the correlation of TCV with patient outcomes.

L-102579-01


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Headshot of Nicholas A. Szugye

Biography

Nicholas A. Szugye

Cincinnati Children’s Hospital Medical Center

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