WEBVTT 00:00:03.771 --> 00:00:05.530 Alright, it's 3 o'clock 00:00:05.530 --> 00:00:08.505 so let's get started. 00:00:08.673 --> 00:00:09.972 My name is Frank, I'm working for 00:00:09.972 --> 00:00:12.947 Materialise and I'm your host for the session today. 00:00:13.072 --> 00:00:16.047 I would like to welcome you and everyone to the webinar 00:00:16.131 --> 00:00:20.489 Scaling Up Medtech Innovation: Elevate Series Manufacturing with 3D Printing. 00:00:21.662 --> 00:00:24.260 We have today with us our speakers, 00:00:24.260 --> 00:00:27.318 Radhika, our Market Manager for Medtech at Materialise, 00:00:28.073 --> 00:00:31.676 and David, a Healthcare and O&P Segment Manager at HP 00:00:32.723 --> 00:00:35.698 Both will share their insights on advanced MedTech with additive manufacturing. 00:00:36.285 --> 00:00:39.050 With deep expertise in 00:00:39.050 --> 00:00:42.193 additive manufacturing and healthcare applications, 00:00:42.612 --> 00:00:44.539 they help to scale innovations 00:00:44.539 --> 00:00:48.017 and 3D printing solutions across the medtech and O&P sectors. 00:00:49.232 --> 00:00:50.950 Both are going to walk you through 00:00:50.950 --> 00:00:54.679 how to take the next step in medtech innovation by using printing for scalable 00:00:54.679 --> 00:00:58.492 series production and by using 3D printing 00:00:59.204 --> 00:01:01.760 for your applications. 00:01:01.760 --> 00:01:03.897 At the end will get advice for 00:01:03.897 --> 00:01:07.375 finding applications, choosing materials, and also developing 00:01:07.836 --> 00:01:10.098 a roadmap alongside. 00:01:10.098 --> 00:01:11.858 For the practical part, 00:01:11.858 --> 00:01:15.042 if you have questions in the meantime, just drop them to the question set. 00:01:15.587 --> 00:01:18.730 You will see that in the operating panel of the software 00:01:19.442 --> 00:01:23.716 and feel free to type them in. We will get to that after the presentation. 00:01:23.925 --> 00:01:27.403 We will read them out loud, and either Radhika 00:01:27.445 --> 00:01:30.587 or David will give the answer to that. For those that don't get answers 00:01:31.802 --> 00:01:34.400 because there are too many at the end and we are running out of time, 00:01:34.400 --> 00:01:38.087 we will be heading after those with you on a one-to-one basis. 00:01:38.716 --> 00:01:40.853 So no questions will be lost at the end. 00:01:42.110 --> 00:01:42.571 So I think at 00:01:42.571 --> 00:01:45.797 this time I would like to hand it over to Radhika, and 00:01:46.551 --> 00:01:49.149 let's get started. Radhika, 00:01:49.149 --> 00:01:51.076 let's go! 00:01:51.076 --> 00:01:54.051 Thanks very much, Frank, for the introduction. 00:01:54.345 --> 00:01:56.691 To all, I'm very pleased to be here today. 00:01:56.691 --> 00:02:00.420 My naam is Radhika, I'm the Market Manager for Medical Technology 00:02:00.420 --> 00:02:02.348 at Materialise. 00:02:02.348 --> 00:02:05.364 I have been at Materialise just over 10 years now 00:02:05.658 --> 00:02:09.512 of which the last three have been focusing on medical technology. 00:02:09.890 --> 00:02:13.996 And within that time, I've really been astonished at the kind of 00:02:13.996 --> 00:02:18.102 innovation that this technology has shown in its application of 3D printing 00:02:18.479 --> 00:02:21.915 and I hope that in today's webinar, we're able to put a spotlight on 00:02:22.753 --> 00:02:25.686 the successful applications, how the companies behind that 00:02:25.686 --> 00:02:28.745 have been able to achieve the successes that they've had. 00:02:29.247 --> 00:02:33.563 And to bring that story together with me I'm very pleased to have here with me today 00:02:33.563 --> 00:02:36.538 David Soriano from HP, our partner, 00:02:37.041 --> 00:02:39.848 who is the producer of Multi Jet Fusion technology. 00:02:41.398 --> 00:02:43.870 And we'll be going into some of these applications 00:02:43.870 --> 00:02:44.918 in detail. 00:02:44.918 --> 00:02:46.426 Now, before we get started, 00:02:46.426 --> 00:02:50.449 I would just like to hear a little bit from you the audience, so 00:02:50.952 --> 00:02:54.723 on the screen now you're seeing a poll. If you look at the top, 00:02:54.723 --> 00:02:58.787 you'll see menti.com. If you could just use your phones to head over to 00:02:58.913 --> 00:03:03.563 menti.com and put in that vote code, you'll be able to answer this question. 00:03:04.024 --> 00:03:07.502 This is one that I would like to ask to understand quickly 00:03:08.131 --> 00:03:10.645 where our audience is today in 00:03:10.645 --> 00:03:14.038 terms of your familiarity with 3D printing for medical technology. 00:03:14.457 --> 00:03:19.234 We know that we're talking to quite a diverse crowd based on the registrations 00:03:19.234 --> 00:03:22.293 that we saw, and I would like to make sure that the 00:03:22.293 --> 00:03:25.310 content that David and I bring is 00:03:25.603 --> 00:03:26.776 at the right level of experience, 00:03:26.776 --> 00:03:30.044 let's say. So if you could take a moment, just head over 00:03:30.086 --> 00:03:33.187 to menti.com, put in the vote code, and 00:03:33.271 --> 00:03:36.287 once you've done that, just keep that tab open on your phone. 00:03:36.287 --> 00:03:40.729 We've got one or the more polls coming in a moment and we'll be able to see 00:03:41.525 --> 00:03:45.589 where we are today. Based on the first quick reactions 00:03:45.589 --> 00:03:49.528 that we can see, again, the diversity of the crowd is confirmed. 00:03:49.528 --> 00:03:51.413 We are all over the place. 00:03:51.413 --> 00:03:56.064 Possibly more with a bias towards the end of the spectrum that has experience 00:03:56.357 --> 00:04:00.841 in 3D printing for end-use parts, which is really excellent because that's 00:04:01.930 --> 00:04:03.145 where we've seen the most 00:04:03.145 --> 00:04:06.916 interesting applications is in series production for 3D printing. 00:04:07.377 --> 00:04:11.693 For those of you that have not yet been actively using 3D printing 00:04:11.693 --> 00:04:13.369 or don't have experience, 00:04:13.369 --> 00:04:16.847 don't worry because we'll also come to the questions of 00:04:16.972 --> 00:04:19.905 how to concretely get started. 00:04:19.905 --> 00:04:23.299 Frank, if you wouldn't mind going over to the next question, please. 00:04:24.263 --> 00:04:26.484 We have one more poll before we get started with 00:04:26.484 --> 00:04:30.003 our content, which is can you 00:04:30.255 --> 00:04:33.565 just name one word that you associate with 3D printing right now? 00:04:34.528 --> 00:04:38.216 We've heard a lot of different kind of perspectives 00:04:38.216 --> 00:04:41.945 from our customers, 3D printing often gets associated with innovation, 00:04:42.992 --> 00:04:46.135 but also the challenges of adoption are ever-present, 00:04:46.135 --> 00:04:46.931 really, 00:04:46.931 --> 00:04:50.408 so I'm curious to understand you as an audience, where 00:04:50.408 --> 00:04:53.509 are you in terms of 3D printing? 00:04:54.976 --> 00:04:55.520 All right, this is very 00:04:55.520 --> 00:04:59.207 interesting to see that we're already seeing an application here in terms of prototyping, 00:04:59.878 --> 00:05:04.194 but also may be some drivers in terms of why you would use 3D printing, 00:05:04.613 --> 00:05:07.587 being innovation and customization. 00:05:08.928 --> 00:05:11.275 This is quite in line with the kind of 00:05:11.275 --> 00:05:13.914 content that we're going to go into. Complexity, also 00:05:13.914 --> 00:05:17.015 that's good to see. Complexity as in design 00:05:17.015 --> 00:05:20.074 complexity, I assume. Definitely one of the important 00:05:20.241 --> 00:05:23.132 drivers for 3D printing. 00:05:23.132 --> 00:05:25.269 Less time consuming. That's an interesting one. 00:05:25.269 --> 00:05:27.616 The person who wrote that. 00:05:27.616 --> 00:05:32.895 I believe we have a case study later that will speak to your interests. All right, Frank, 00:05:32.895 --> 00:05:36.498 with that said, I believe we can get started with the next slide. 00:05:37.755 --> 00:05:42.239 Now, Materialise started as a company in 1990, and the very 00:05:42.239 --> 00:05:46.177 vertical or industry that the company entered was the medical vertical. 00:05:46.638 --> 00:05:49.906 And that was because of what you see here at the left end of the spectrum 00:05:49.906 --> 00:05:53.091 personalized implants, guides, and models. So I would say that 00:05:53.719 --> 00:05:56.150 where printing for medtech is 00:05:56.150 --> 00:06:00.214 a very mature industry, literally starting since the early 90s, 00:06:00.968 --> 00:06:04.236 possibly most of the spotlight goes to that left end of the spectrum, 00:06:04.236 --> 00:06:05.535 which is patient-specific care. 00:06:06.918 --> 00:06:10.018 Now, here really the advantage of 3D printing 00:06:10.018 --> 00:06:14.544 or the reason why companies are using it, is because it improves surgical outcomes, 00:06:14.544 --> 00:06:17.686 which for patients means more minimally 00:06:17.770 --> 00:06:20.745 invasive surgery, faster recovery times. 00:06:21.164 --> 00:06:23.678 What's also interesting to me is that over the 00:06:23.678 --> 00:06:26.695 last maybe ten years, we've seen 00:06:26.820 --> 00:06:30.256 a great slew of applications on the standardized end of the spectrum. 00:06:30.591 --> 00:06:33.566 And here we're talking parts for machinery and equipment. 00:06:34.404 --> 00:06:36.541 And here the drivers for 3D printing 00:06:36.541 --> 00:06:38.510 are really completely different. 00:06:38.510 --> 00:06:41.527 We have customers who use 3D printing to 00:06:41.653 --> 00:06:44.544 produce parts for bioreactors, parts for 00:06:44.544 --> 00:06:48.776 cancer care equipment, hospital equipment, even micro-surgery robots, 00:06:49.279 --> 00:06:53.008 and those parts are all standardized, right? They're produced in small series. 00:06:53.008 --> 00:06:55.145 They're not custom. 00:06:55.145 --> 00:06:59.335 But the reason why they're using 3D printing is mainly around supply chain agility, 00:06:59.712 --> 00:07:04.405 so the ability to produce parts on demand when you need them, where you need them 00:07:05.201 --> 00:07:07.631 in small series so you can produce very 00:07:07.631 --> 00:07:10.606 niche machines for niche applications. 00:07:10.732 --> 00:07:14.251 And that's an area that we're really seeing growing. 00:07:15.508 --> 00:07:17.603 Somewhere between these two realities, 00:07:17.603 --> 00:07:22.170 so personalization and standardization, there is orthotics and prosthetics, 00:07:22.170 --> 00:07:26.235 which has been a very successful adopter of 3D printing. 00:07:27.114 --> 00:07:29.880 where we see that orthotics and prosthetics is using 3D 00:07:29.880 --> 00:07:32.897 printing, regardless of whether the end product is standardized 00:07:33.986 --> 00:07:35.536 or patient-specific. 00:07:35.536 --> 00:07:38.930 Now here the drivers tend to be mainly around the ability to automate 00:07:39.140 --> 00:07:42.408 design and simplify workflows. Multi Jet 00:07:42.408 --> 00:07:45.425 Fusion from HP has especially had a lot of 00:07:45.425 --> 00:07:49.615 good success in this area, which is why I'm very glad to have David with us here 00:07:49.699 --> 00:07:53.344 today, who will go into detail on exactly what 00:07:53.470 --> 00:07:57.366 HP has been seeing in this O&P, or orthotics and prosthetics, space. 00:07:57.953 --> 00:08:02.143 So looking at all of this, for your the audience, 00:08:02.269 --> 00:08:05.243 if we go over to the next slide, we have another quick poll. 00:08:05.872 --> 00:08:06.961 What drives you to 00:08:06.961 --> 00:08:12.408 consider 3D printing today? I'm putting on the slide here a few examples that 00:08:12.408 --> 00:08:17.981 we've seen from our customers so far, ranging from economic drivers such as avoiding 00:08:18.316 --> 00:08:21.501 tooling cost, to eliminating minimum order quantities 00:08:21.836 --> 00:08:25.649 to the other end of the spectrum with design complexity or being able to 00:08:26.026 --> 00:08:29.671 produce parts that you would not be able to produce with traditional manufacturing. 00:08:30.593 --> 00:08:33.484 If you could take a moment, just drag and drop those 00:08:33.484 --> 00:08:37.255 into the ranks in which they matter to you. We can pick that up 00:08:37.255 --> 00:08:41.906 at a later point point to see how these different drivers 00:08:43.079 --> 00:08:46.096 affect your decision-making in 3D printing. 00:08:46.515 --> 00:08:49.490 Now, if we're looking at 00:08:49.490 --> 00:08:53.554 the applications that I previously spoke of, so patient-specific 00:08:53.931 --> 00:08:56.906 versus the standardized components versus O&P, 00:08:57.409 --> 00:09:01.138 oh there we go we're already starting to see some interesting developments over here. 00:09:02.060 --> 00:09:06.962 Avoiding tooling cost is definitely winning, which really means the small 00:09:06.962 --> 00:09:11.990 series is an important driver for US all, which makes sense considering 00:09:12.116 --> 00:09:15.133 that as innovation starts to create more niche products, 00:09:15.300 --> 00:09:18.317 you don't want to mass manufacture those, and 3D printing 00:09:18.359 --> 00:09:21.041 really comes into its own with that. 00:09:21.041 --> 00:09:23.219 If I look at the first three there 00:09:23.219 --> 00:09:26.446 with the avoiding of tooling cost, design complexity, faster 00:09:26.446 --> 00:09:29.462 time-to-market, and even avoiding MOQs, 00:09:30.007 --> 00:09:31.097 There's one sub-segment 00:09:31.097 --> 00:09:32.940 of medtech that really jumps out 00:09:32.940 --> 00:09:37.842 as it's one with one of these apply, which is orthotics and prosthetics. 00:09:38.387 --> 00:09:42.074 So with that, I'm going to hand over to David to understand 00:09:42.451 --> 00:09:45.803 what kind of challenges is 3D printing helping O&Ps solve today? 00:09:48.024 --> 00:09:50.203 Yes, thank you, Radhika, and good morning and good afternoon, everyone. 00:09:50.203 --> 00:09:54.435 Very happy to be here and thankful to the Materialise team to 00:09:54.812 --> 00:09:56.153 organize this session with us. 00:09:56.153 --> 00:09:59.128 Happy to share some of the things that we've seen, 00:10:00.091 --> 00:10:02.019 in O&P, as Frank mentioned in the beginning, 00:10:02.019 --> 00:10:06.125 I am the segment manager for healthcare and particularly orthotics 00:10:06.251 --> 00:10:09.309 and prosthetics at HP additive manufacturing so 00:10:10.147 --> 00:10:14.505 again, as Radhika was saying, what do we see as challenges today in O&P, which is 00:10:15.259 --> 00:10:18.276 an industry where we see a lot of adoption in 00:10:18.318 --> 00:10:22.047 3D printing. For the ones of you who might have been 00:10:22.047 --> 00:10:23.932 there know about it, last week, 00:10:23.932 --> 00:10:28.458 there was a big conference called ISBO happening in Stockholm, Sweden 00:10:29.170 --> 00:10:33.360 it's one of the biggest happening in the world and it was very, very interesting 00:10:33.360 --> 00:10:36.712 to see the variety of applications and also how much 00:10:37.424 --> 00:10:41.028 3D printing is already starting to be present in this kind of industry. 00:10:41.447 --> 00:10:44.882 And this is somehow responding to some of the challenges that we 00:10:45.176 --> 00:10:48.695 see here, right? So, on one side, when we think about O&P 00:10:48.737 --> 00:10:51.964 devices, we have a clinician in contact with the patient. 00:10:52.676 --> 00:10:55.693 That might need a device that will be manufactured for 00:10:56.028 --> 00:10:59.715 for this patient through a technician or the clinician themselves. It can be 00:11:01.307 --> 00:11:02.229 also a central fab 00:11:02.229 --> 00:11:06.251 or a medical equipment provider, so you have different players that are here. 00:11:06.796 --> 00:11:09.352 But all of these devices in the end have 00:11:09.352 --> 00:11:12.914 something in common, which is that they tend to be very labor-intensive. 00:11:13.500 --> 00:11:15.972 These devices take time to make, they're 00:11:15.972 --> 00:11:19.199 done manually following traditional processes, 00:11:19.199 --> 00:11:23.221 some of them are slowly transitioning into other technologies 00:11:23.514 --> 00:11:27.076 like CNC machining and then, in the end, 3D printing. 00:11:27.076 --> 00:11:30.470 But when you think about the essence and the origin of this, 00:11:31.098 --> 00:11:35.623 it takes a long time. When you think about a pair of insoles, for example, a pair of insoles 00:11:35.917 --> 00:11:39.730 would take around 20 minutes to make, which in the end takes quite a significant 00:11:39.730 --> 00:11:42.704 amount of time, taking to account how small this part is. 00:11:42.872 --> 00:11:46.098 And the fact that this is being done by a human being always has, 00:11:46.434 --> 00:11:49.450 despite the fact that we have people who are 00:11:49.450 --> 00:11:53.221 specialists in this very, very specific kind of 00:11:55.274 --> 00:11:58.249 background to be able to do these kinds of devices, 00:11:58.249 --> 00:12:00.680 there is always the possibility to have the human error 00:12:00.680 --> 00:12:03.654 factor in the manufacturing of those parts. 00:12:04.367 --> 00:12:08.892 Another of the challenges that we think about is that whenever we have a patient, 00:12:09.018 --> 00:12:11.951 so for example, Radhika goes to a clinic, she is going 00:12:11.951 --> 00:12:14.926 to be a patient for an O&P device. 00:12:15.051 --> 00:12:18.026 The doctor, we have all the information about Radhika. 00:12:18.026 --> 00:12:23.641 They will know the name, they will know her ID, they will know her age, they will know her weight, 00:12:23.641 --> 00:12:27.621 they will know the difference sizes they need for the particular part of the body, where they 00:12:28.166 --> 00:12:29.130 will need to build this O&P device. 00:12:29.130 --> 00:12:30.848 And this is all very good information. 00:12:30.848 --> 00:12:33.864 The problem is that we will always be missing 00:12:33.990 --> 00:12:38.390 the real information about the final part. That we're going to be doing this part. 00:12:38.473 --> 00:12:42.915 We don't have a digital copy or equivalent of how this part is going to look, 00:12:43.543 --> 00:12:47.230 which in the end poses problems whenever it comes to traceability of what is 00:12:47.230 --> 00:12:50.205 the treatment that this patient has been following or if 00:12:50.331 --> 00:12:55.485 tomorrow Radhika goes running and for whatever reason, 00:12:55.904 --> 00:12:58.879 her insole breaks and we need to build a new one. 00:12:59.256 --> 00:13:02.189 We don't have a digital model that allows us to replicate. 00:13:02.189 --> 00:13:05.206 exactly the insole that she was wearing to make sure that 00:13:05.206 --> 00:13:08.222 it matches exactly the treatment that she was following. 00:13:08.264 --> 00:13:09.647 So here, 00:13:09.647 --> 00:13:10.946 one of the challenge is that, again, 00:13:10.946 --> 00:13:13.921 we don't have the digital data of the final part 00:13:13.921 --> 00:13:16.896 that we're producing. Scalability is very expensive. 00:13:16.896 --> 00:13:18.739 So if I am a clinic and I want to 00:13:18.739 --> 00:13:21.924 continue expanding in volume, number of patients, and reach, 00:13:22.762 --> 00:13:27.413 what I need is a lot of space to be able to store all the material 00:13:27.454 --> 00:13:30.639 that I'm going to need to build all those devices, but also 00:13:31.184 --> 00:13:33.656 the number of operators. So, the operators we mentioned 00:13:33.656 --> 00:13:37.343 I mentioned earlier that this people have very specific training. 00:13:37.888 --> 00:13:40.569 They are very knowledge about what they do. 00:13:40.569 --> 00:13:43.586 These operators, we don't find that many of them anymore 00:13:43.879 --> 00:13:46.896 and they have a certain cost associated as well. 00:13:46.980 --> 00:13:51.086 So the more we expand, the more our cost is also going to increase in having more 00:13:51.086 --> 00:13:54.564 operators that are able to manufacture those devices, which for some of the 00:13:54.564 --> 00:13:58.335 applications make a lot of sense, so I'm not saying get rid of those operators. 00:13:58.544 --> 00:14:02.148 These operators are one 100% needed for some of the applications and you will want 00:14:02.148 --> 00:14:02.986 to keep them. 00:14:02.986 --> 00:14:07.259 But maybe for some other tasks, you might not need that anymore or it 00:14:07.259 --> 00:14:10.695 might be limiting for you to think about continuing to stay. 00:14:11.449 --> 00:14:13.880 And then another of the challenges that we see is the very 00:14:13.880 --> 00:14:17.106 high volumes of waste. Again, back to example of an insole. 00:14:17.693 --> 00:14:22.176 A pair of insoles is roughly 180 grams, 200 grams, let's say. 00:14:22.972 --> 00:14:26.198 Using traditional manufacturing for every pair of 00:14:26.198 --> 00:14:29.969 insoles that we're producing, there is around 1.8 kilos of waste 00:14:30.556 --> 00:14:33.112 that are going to be thrown away directly. 00:14:33.112 --> 00:14:36.589 If you do the quick math of having to starting to scale with this, 00:14:36.715 --> 00:14:39.941 the amount of waste that you're generating every day, every week, every month, 00:14:40.277 --> 00:14:43.252 every year becomes very, very substantial. 00:14:43.335 --> 00:14:46.729 So here again, there is a lot of waste generated that, 00:14:47.064 --> 00:14:50.710 at the same time before throwing it away, also needs to be stored 00:14:51.003 --> 00:14:53.727 for some because of it needs to be kept in terms of 00:14:54.774 --> 00:14:56.743 records. 00:14:56.743 --> 00:14:59.090 To keep as a record for the patients. 00:14:59.090 --> 00:15:00.137 If we move to the next slide, 00:15:00.137 --> 00:15:03.489 this is where we want to see how additive manufacturing, and in particular, 00:15:03.531 --> 00:15:06.590 MJF, is trying to tackle those different challenges, and we 00:15:06.590 --> 00:15:09.858 tried to think about those in two different categories. On one side, 00:15:09.858 --> 00:15:11.869 we have the product differentiation. 00:15:11.869 --> 00:15:14.844 And on the other side, we have the workflow simplification. 00:15:14.886 --> 00:15:17.358 When we think about product differentiation, we have 00:15:17.358 --> 00:15:20.836 improved functionality that we can put into these different devices. 00:15:21.381 --> 00:15:23.853 One of them is that through additive manufacturing, 00:15:23.853 --> 00:15:27.456 we can make a part less bulky, thinner walls. 00:15:28.378 --> 00:15:31.395 We can put holes in the structure like the ones you can see in the picture. 00:15:31.730 --> 00:15:34.872 Uh, we can put devices that are a bit more breathable, which 00:15:35.208 --> 00:15:39.104 also have in terms of lightweighting, but it has been proven 00:15:39.104 --> 00:15:42.205 and I have an example here of a part that we that we have. 00:15:42.205 --> 00:15:45.222 You can also see it in the picture. 00:15:45.264 --> 00:15:47.526 This is something that would replace, 00:15:47.526 --> 00:15:52.177 it's an arm brace that could replace a normal cast. What has been proven is the fact that this 00:15:52.638 --> 00:15:57.415 device, it has exactly the same functionality. It is rigid so the arm will be safe. 00:15:57.834 --> 00:16:00.808 The bone will be able to repair. But the fact 00:16:00.808 --> 00:16:03.825 that this structure is breathable also helps accelerate a lot 00:16:04.077 --> 00:16:07.554 the recovery of the patient afterwards versus the traditional cast that we 00:16:07.680 --> 00:16:13.462 would be using where the arm would come out being a lot skinnier, feeling a lot weaker, 00:16:13.462 --> 00:16:18.239 and it would take long time to get to a full recovery of the patient. 00:16:19.412 --> 00:16:20.376 Design freedom, again, 00:16:20.376 --> 00:16:23.560 this is where we can do parts that are really complicated to do 00:16:23.602 --> 00:16:28.881 with traditional manufacturing, but also again enabling this lightweight 00:16:28.881 --> 00:16:33.113 through lattice structure that in the end are going to have a direct impact on patient comfort. 00:16:33.532 --> 00:16:36.591 Patient comfort, apart from the treatment that works well, 00:16:37.010 --> 00:16:41.661 patient comfort for all of the O&P people is one of the top 00:16:41.661 --> 00:16:45.348 metrics here to make sure that the patient has the best possible experience 00:16:45.558 --> 00:16:49.538 while making sure that the treatment is working well. So this would 00:16:49.538 --> 00:16:52.723 be the part of the product differentiation. Workflow simplification, again, 00:16:52.723 --> 00:16:56.619 we spoke about how long the manufacturer 00:16:56.619 --> 00:16:59.929 of those devices can be sometimes. Thanks to MJF, 00:16:59.929 --> 00:17:03.742 and if we optimized well, the build size that we have, and the 00:17:04.161 --> 00:17:07.848 parts that we're putting in it, we can really increase the productivity here. 00:17:08.309 --> 00:17:12.206 Thanks to the different capabilities that you have with optimizing the nesting, 00:17:12.709 --> 00:17:17.569 we can go to with one single printer printing two buckets per day, 00:17:17.611 --> 00:17:21.717 we can print up to 100 pairs every single day 00:17:23.393 --> 00:17:25.195 of those insoles in the MJF, 00:17:25.195 --> 00:17:29.008 which increases the throughput a lot versus what we were talking about by doing them manually. 00:17:30.139 --> 00:17:32.109 The predictable time-to-part, again, 00:17:32.109 --> 00:17:34.664 through MJF we know exactly how much time it takes to print 00:17:34.664 --> 00:17:37.807 the full bucket, so depending on the amount of parts that your 00:17:37.807 --> 00:17:40.866 nesting in here and the height that you're putting in the 00:17:40.866 --> 00:17:44.427 volume, you know exactly how much time it's going to take you within the moment you hit the 00:17:44.720 --> 00:17:47.737 print button until the moment you get the parts out of the printer. 00:17:48.366 --> 00:17:51.634 And then, we mentioned as well before, the 00:17:51.843 --> 00:17:55.908 huge amount of waste that we're generating in traditional processes here. 00:17:56.327 --> 00:17:59.008 The MJF, the part that we're using, the powder, 00:17:59.008 --> 00:18:00.642 we're using the agents. 00:18:00.642 --> 00:18:04.455 A very big portion of this powder is going to be recycled for the next cycle, 00:18:04.749 --> 00:18:08.226 so the fact that we are trying to optimize the use of this powder is 00:18:08.226 --> 00:18:11.411 also going to very greatly contribute to the reduction of the waste that we're 00:18:11.411 --> 00:18:12.374 going to be generating. 00:18:13.380 --> 00:18:13.967 And all of that, 00:18:13.967 --> 00:18:15.936 in the end, if we go to the next slide. 00:18:15.936 --> 00:18:19.916 It's to create a very range of devices in orthotics and prosthetics. 00:18:20.377 --> 00:18:21.844 I have a few here with me. 00:18:21.844 --> 00:18:26.243 You have the cranial helmet for infants. 00:18:26.453 --> 00:18:27.417 that is being used. 00:18:27.417 --> 00:18:29.512 This is an example from Invent Medical. 00:18:29.512 --> 00:18:30.224 You can see here, 00:18:30.224 --> 00:18:33.199 we have many different examples of 00:18:34.246 --> 00:18:34.791 insoles. 00:18:34.791 --> 00:18:37.766 Some countries prefer the lattice versions 00:18:37.933 --> 00:18:41.034 that you can see through here, others refer to the more rigid version. 00:18:41.663 --> 00:18:43.045 I showed before as well, 00:18:43.045 --> 00:18:46.104 this hand brace. Other devices like 00:18:47.361 --> 00:18:50.336 AFOs that I have here. 00:18:50.462 --> 00:18:53.478 Other designs...and then we have other 00:18:53.478 --> 00:18:57.291 kind of devices that are still in orthotics and on the right side 00:18:57.291 --> 00:19:00.224 you can see a few devices that are on the prosthetics side. 00:19:00.224 --> 00:19:04.247 Prosthetic sockets, prosthetic arms, and even prosthetic covers to cover 00:19:04.414 --> 00:19:08.060 the socket to make them visually more attractive. 00:19:09.442 --> 00:19:09.819 And from 00:19:09.819 --> 00:19:14.051 here, what we wanted to do as well after having a bit of an overview is to 00:19:14.596 --> 00:19:17.738 understand and sharing the challenges in O&Ps. Sharing 00:19:17.738 --> 00:19:21.216 what are somehow the biggest challenges that hold you back when you want to 00:19:21.216 --> 00:19:25.029 scale in additive manufacturing or even for the ones of you don't have experience, 00:19:25.029 --> 00:19:28.046 there, the ones that are holding you back into actually starting to 00:19:28.591 --> 00:19:31.230 try and experience additive manufacturing. 00:19:31.230 --> 00:19:32.194 So again, 00:19:32.194 --> 00:19:36.300 same webpage, same code. We would really like to hear your feedback 00:19:36.300 --> 00:19:40.155 or a word, that for you would be a good representation of what would be 00:19:40.281 --> 00:19:43.297 this challenge. 00:19:43.968 --> 00:19:44.932 Absolutely, thanks, 00:19:44.932 --> 00:19:48.535 David for the introduction and the overview on orthotics and prosthetics. 00:19:49.038 --> 00:19:52.390 I hope that also to those working in other parts 00:19:52.390 --> 00:19:55.826 of the medtech industry that is can serve as an inspiration. 00:19:56.328 --> 00:20:00.351 I really think that O&P is one of the shining success 00:20:00.351 --> 00:20:04.373 stories in the way that they have managed to formulate entire business models 00:20:04.415 --> 00:20:07.893 around the possibilities of 3D printing, going from 00:20:07.893 --> 00:20:11.873 digital input to mass customized products. But 00:20:12.837 --> 00:20:15.477 even though the drivers are similar, on the other hand, I think 00:20:15.477 --> 00:20:18.493 that the challenges, some of which David already touched on, 00:20:18.493 --> 00:20:21.762 like scalability, traceability, sustainability, 00:20:22.139 --> 00:20:26.748 these are all things that 3D printing can help with, but at the same thing also 00:20:27.292 --> 00:20:30.267 are not necessarily easy to solve in 3D printing either. 00:20:30.603 --> 00:20:33.955 So, on that front, it's it's interesting to hear 00:20:34.164 --> 00:20:38.480 what you see is the biggest challenge holding you back in scaling AM now. 00:20:39.946 --> 00:20:43.047 We're seeing cost, definitely unit cost. 00:20:43.047 --> 00:20:47.656 can be a concern depending on the kind of application. Internal knowledge. 00:20:47.656 --> 00:20:50.715 That's a very good one and of course can go anywhere from 00:20:51.385 --> 00:20:54.360 design-related knowledge to compliance-related knowledge. 00:20:55.240 --> 00:20:57.628 Design for additive as well. 00:20:57.628 --> 00:21:00.226 On some of these topics, 00:21:00.226 --> 00:21:05.128 working together with a 3D printing supplier can be helpful way to build 00:21:05.128 --> 00:21:09.025 up that internal knowledge, specifically when it comes to design for AM. 00:21:09.737 --> 00:21:11.748 If that can be a topic of interest, 00:21:11.748 --> 00:21:14.975 always feel free to reach out to us. I'll make sure 00:21:14.975 --> 00:21:18.075 to put some contact details at the end of the presentation. 00:21:19.081 --> 00:21:20.715 Finding the correct material. 00:21:20.715 --> 00:21:23.983 That's a good one that we're actually going to come to very shortly now. 00:21:24.863 --> 00:21:29.514 In addition to the content that we're seeing on the slide here today, 00:21:29.933 --> 00:21:32.782 one topic that comes back to us that we hear about 00:21:32.782 --> 00:21:35.757 a lot is regulatory compliance, 00:21:36.260 --> 00:21:38.732 which is one that I would like to go over on 00:21:38.732 --> 00:21:41.665 the next slide and especially, 00:21:41.665 --> 00:21:45.855 depending on the kind of device that you have in mind, the way that 00:21:46.232 --> 00:21:49.919 compliance or quality requirements are built up can be really diverse. 00:21:50.380 --> 00:21:53.355 So some time ago I showed the scale 00:21:53.397 --> 00:21:57.922 or the spectrum going from patient-specific applications to standardized applications. 00:21:58.425 --> 00:22:01.735 Here let's look at more or less that same spectrum, but now 00:22:01.735 --> 00:22:04.710 organized along risk and criticality. 00:22:04.710 --> 00:22:08.146 So this is the standard medical devices classification 00:22:08.146 --> 00:22:11.665 as the EU MDR or the Medical Devices Regulation 00:22:11.833 --> 00:22:12.210 sees it. 00:22:13.216 --> 00:22:13.928 In the EU, 00:22:13.928 --> 00:22:18.998 we have four classes really. So, class one being the ones with the least risk, the 00:22:18.998 --> 00:22:22.350 least invasive devices, which is where you see eyewear 00:22:22.350 --> 00:22:25.367 for example, but also orthotics. 00:22:25.911 --> 00:22:29.682 Class two is a huge class that, according to some studies 00:22:29.682 --> 00:22:33.705 even comprises about 80 percent of the market in medical devices 00:22:34.208 --> 00:22:38.146 and range everywhere from hospital equipment to 00:22:38.481 --> 00:22:43.970 even some parts of micro-surgery robots, which do penetrate body cavities. 00:22:43.970 --> 00:22:46.945 So, for example, can be surgical instrumentation, 00:22:47.280 --> 00:22:51.303 but are short-term use. On the other hand, with class three, 00:22:51.303 --> 00:22:55.283 which is the most critical or the highest risk class device, we're talking 00:22:55.283 --> 00:23:00.605 about life-sustaining devices that are implantables. Now, what's interesting to 00:23:00.605 --> 00:23:06.052 note is that 3D printing is already being used throughout this pyramid. So, in Materialise, 00:23:06.261 --> 00:23:08.775 we have a business division. 00:23:08.775 --> 00:23:10.870 that focuses entirely on eyewear. 00:23:10.870 --> 00:23:14.473 Another subsidiary that focuses on orthotics. 00:23:14.934 --> 00:23:17.867 Some of the cases that we're going to be showing you today are in that 00:23:17.867 --> 00:23:20.842 middle layer, the class 2A and 2B, 00:23:20.926 --> 00:23:25.786 and the Materialise Medical business unit focuses on patient-specific devices, 00:23:26.164 --> 00:23:30.437 including surgical guides and implants, which are in the class three segment. 00:23:31.527 --> 00:23:34.795 The diversity of the product lines here, I really can't 00:23:34.795 --> 00:23:39.111 overstate that. Product requirements at the top and at the bottom here are 00:23:39.111 --> 00:23:44.348 usually different, ranging anywhere from only biocompatibility to 00:23:44.348 --> 00:23:48.706 full biocompatibility assessments and at a very stringent level, too. 00:23:49.586 --> 00:23:53.901 so what we will do next is to maybe a quick deep dive into 00:23:54.237 --> 00:23:58.804 quality and what quality means and how 3D printing can assure it. 00:23:59.390 --> 00:24:04.041 So, let's take a quick look here at how quality is built up 00:24:04.376 --> 00:24:07.393 in a traditional manufacturing set up. You see a chair there. 00:24:07.854 --> 00:24:10.494 You can picture that being manufactured in traditional 00:24:10.494 --> 00:24:13.511 manufacturing, let's say injection molding. 00:24:13.552 --> 00:24:15.773 Now, about half of the 00:24:15.773 --> 00:24:18.748 quality of that chair is determined by 00:24:19.209 --> 00:24:22.477 the material design and the material. 00:24:22.896 --> 00:24:28.008 The material and the design together. The production process, which is very stable in 00:24:28.008 --> 00:24:31.821 traditional manufacturing, is a relatively smaller contributor 00:24:31.821 --> 00:24:36.346 to the eventual quality. On the other hand, with 3D printing, 00:24:36.639 --> 00:24:40.285 we see that balance really shifting. On the next slide, 00:24:40.285 --> 00:24:45.774 please, Frank, we'll see how that divide works in 3D printing. Here, suddenly 00:24:45.774 --> 00:24:51.262 design tends to play a much bigger role in the eventual quality of the part. 00:24:51.262 --> 00:24:51.765 Or the product, let's say. 00:24:52.938 --> 00:24:55.913 And the reason for that is 00:24:55.997 --> 00:24:59.140 that the printing process and the design together are 00:24:59.182 --> 00:25:03.288 really creating the product characteristics in process. 00:25:03.707 --> 00:25:07.771 And we're eventually going to go into detail on exactly how that looks in 00:25:07.771 --> 00:25:11.374 terms of the Multi Jet Fusion technology specifically. 00:25:11.961 --> 00:25:14.894 On the next slide, please, Frank. 00:25:14.894 --> 00:25:16.696 You've got a quick overview here 00:25:16.696 --> 00:25:19.587 of the variables that come to play 00:25:19.587 --> 00:25:23.358 during the production of Multi Jet Fusion, as an example 00:25:23.358 --> 00:25:24.699 here. 00:25:24.699 --> 00:25:27.674 All of these variables will eventually impact 00:25:27.674 --> 00:25:30.229 the quality of your printed part. 00:25:30.229 --> 00:25:32.199 These are the process characteristics, so for 00:25:32.199 --> 00:25:35.216 example, what sort of mix ratio you use 00:25:35.509 --> 00:25:38.526 between the old powder and new powder, or 00:25:38.693 --> 00:25:41.668 virgin powder versus recycled powder, let's say. 00:25:42.213 --> 00:25:45.230 How degraded that powder was, 00:25:45.230 --> 00:25:49.797 or even on the machine side, the recoater state and the thermal camera state. 00:25:50.258 --> 00:25:54.615 All of these variables will eventually impact the quality of your printed 00:25:54.615 --> 00:25:57.590 part. These are 00:25:57.674 --> 00:26:00.649 typically variables that if you are 00:26:01.026 --> 00:26:05.593 working with a service provider like Materialise, you may not necessarily 00:26:05.677 --> 00:26:10.160 need granular detail on how all of these processes are set. 00:26:10.663 --> 00:26:12.255 But what you do need 00:26:12.255 --> 00:26:16.990 an understanding of is that they're stable. That if you order a part one day and then a hundredth 00:26:17.954 --> 00:26:19.378 part in the same series 00:26:19.378 --> 00:26:22.395 that the characteristics of each are identical, 00:26:23.107 --> 00:26:27.088 which can be a really important contributor to eventual part 00:26:27.968 --> 00:26:30.984 quality and, ultimately, 00:26:32.074 --> 00:26:33.834 decisions that are taken in the 00:26:33.834 --> 00:26:38.233 production process will also impact factors such as 00:26:38.233 --> 00:26:42.423 biocompatibility which can be important quality metrics 00:26:42.716 --> 00:26:45.733 in the medical technology sector. 00:26:45.733 --> 00:26:49.001 Since biocompatibility is one of the topics that we're asked about the most, 00:26:49.337 --> 00:26:53.024 I would like to, on the next slide, go into that one in more 00:26:53.610 --> 00:26:56.627 detail and specifically how 00:26:56.627 --> 00:26:59.979 the 3D printing industry ensures biocompatibility. 00:27:00.482 --> 00:27:04.504 It's a complicated topic because you've just heard how many different variables 00:27:04.504 --> 00:27:09.281 come in to play in the production of 3D- printed parts and also when it comes. 00:27:09.281 --> 00:27:11.250 to assuring biocompatibility. 00:27:11.250 --> 00:27:13.722 There are many different 00:27:13.722 --> 00:27:16.739 ways that the 3D printing industry approaches this topic. 00:27:17.242 --> 00:27:20.217 So, it all starts from the raw material. 00:27:21.055 --> 00:27:24.281 If the raw material is not biocompatible, then there is no 00:27:24.281 --> 00:27:28.178 3D printing process that is going to make it so. An exception 00:27:28.178 --> 00:27:29.603 there is resins which are not biocompatible. 00:27:29.603 --> 00:27:32.577 in their raw state but will become so 00:27:32.996 --> 00:27:36.013 potentially after being solidified. 00:27:36.474 --> 00:27:38.695 But by and large, let's say, the material 00:27:38.695 --> 00:27:41.837 itself needs to be biocompatible at its base. 00:27:43.094 --> 00:27:43.974 That's a claim that 00:27:43.974 --> 00:27:46.991 comes from the material manufacturer. 00:27:47.033 --> 00:27:51.013 So in our case, working together with HP for Multi Jet Fusion, 00:27:51.013 --> 00:27:52.731 for example, 00:27:52.731 --> 00:27:54.826 material suppliers could be US 00:27:54.826 --> 00:27:57.215 Arkema, for example, that 00:27:57.215 --> 00:27:59.100 produce materials like PA 12 or 00:27:59.100 --> 00:28:02.117 TPU or PA 11. 00:28:02.662 --> 00:28:07.187 The material manufacturer themselves does some due diligence to ensure that 00:28:07.313 --> 00:28:10.287 the material can be claimed as biocompatible. 00:28:10.916 --> 00:28:13.681 Then, we, as a service provider, 00:28:13.681 --> 00:28:17.871 Materialise, is responsible for the manufacturing process. What we 00:28:17.871 --> 00:28:21.642 have to do is to make sure that nothing is introduced into the process that 00:28:21.978 --> 00:28:25.162 messes with the inherent biocompatibility of the material. 00:28:25.874 --> 00:28:29.352 This is a claim that you will only get from the service provider because we're 00:28:29.478 --> 00:28:33.835 the ones responsible for the process and by the process I don't just mean 00:28:33.835 --> 00:28:37.900 the printing, but also post-production, finishing, assembly, gluing, 00:28:38.360 --> 00:28:43.514 whatever might happen as your part becomes a product. And then, 00:28:43.514 --> 00:28:48.081 ultimately, you have the product, which is after it's been assembled, glued, any 00:28:49.464 --> 00:28:51.852 post-process finishing has been applied to it. 00:28:51.852 --> 00:28:54.743 Is that product now biocompatible? 00:28:54.743 --> 00:28:57.802 That's a test that has to be conducted by the legal 00:28:57.802 --> 00:29:01.280 device manufacturer. For us as a contact manufacturer, 00:29:01.531 --> 00:29:03.752 that mostly means that it's our customers 00:29:03.752 --> 00:29:06.559 who are the legal device manufacturers. 00:29:06.559 --> 00:29:08.780 Who take responsibility for the 00:29:08.780 --> 00:29:11.755 biocompatibility of the final end-product. 00:29:11.755 --> 00:29:15.610 Now keep in mind that all of these levels can be applied to 00:29:15.610 --> 00:29:19.506 different standards in biocompatibility, of which the one that we get 00:29:19.590 --> 00:29:23.906 ask for the most oven is cytotoxicity, so ISO 10993-5. 00:29:24.534 --> 00:29:27.635 What we do as 00:29:28.180 --> 00:29:30.652 a material manufacturer - as a 00:29:30.652 --> 00:29:35.596 3D printing service provider is we take materials that are biocompatible and, depending 00:29:35.596 --> 00:29:41.881 on what sort of finish you need, we can produce sample of it and have that tested 00:29:41.881 --> 00:29:45.317 for biocompatibility. That way you can assured that 00:29:46.113 --> 00:29:50.722 the material manufacturers' word, you don't have to take it at face value, that you know 00:29:50.722 --> 00:29:56.294 that your parts pass the test also after having been through the Materialise process. 00:29:57.761 --> 00:29:59.186 On the next slide, 00:29:59.186 --> 00:30:03.962 we will look at how these requirements map against different applications. 00:30:04.465 --> 00:30:07.440 We talked briefly before about the different risk levels, 00:30:08.278 --> 00:30:11.588 but there's also of course different applications. A housing 00:30:11.588 --> 00:30:14.689 or a cover in a surgical robot will have different 00:30:14.982 --> 00:30:18.795 requirements compared to the tip or the instrument end of that robot 00:30:18.795 --> 00:30:22.985 that's actually in contact with the patient. So depending on the application, 00:30:22.985 --> 00:30:27.133 that you're talking about, your product requirements will also be quite diverse. 00:30:27.803 --> 00:30:31.742 Here you see a quick overview of, depending on what you're printing, 00:30:32.203 --> 00:30:36.016 what kind of material and technology we recommend 00:30:36.016 --> 00:30:38.362 for that. 00:30:38.362 --> 00:30:42.007 Next to this, it's quite a lot of information on this slide. 00:30:42.343 --> 00:30:47.538 We do have a downloadable guide for this so I'll also put that in the 00:30:47.538 --> 00:30:51.896 chat after this so that you are able to download that and review it at your own time. 00:30:53.656 --> 00:30:55.625 Now, HP, as a 00:30:55.625 --> 00:30:59.061 manufacturer of machines has also invested 00:30:59.061 --> 00:31:02.748 quite a lot in the testing of biocompatibility of their materials. 00:31:03.209 --> 00:31:03.502 David, 00:31:03.502 --> 00:31:06.812 is there anything that you'd like to share on HP's work there? 00:31:07.734 --> 00:31:08.279 Yeah, sure. 00:31:08.279 --> 00:31:12.804 So if we look at the next slide, you can see the on the right-hand 00:31:12.804 --> 00:31:16.282 side, this is something that we have available on the web that 00:31:16.575 --> 00:31:19.340 can be downloaded where you can see in the different columns 00:31:19.340 --> 00:31:22.692 the different materials that we have for 00:31:22.734 --> 00:31:26.128 MJF and then in the rows you will see the different 00:31:26.673 --> 00:31:30.988 tests that have been performed, where you can see 00:31:30.988 --> 00:31:35.388 which materials qualify for which kind of requirements that you might need. 00:31:36.016 --> 00:31:39.620 Because in the end, as you can see on the pictures, all of 00:31:39.746 --> 00:31:42.762 these parts are going to be in contact with the 00:31:43.349 --> 00:31:47.623 human skin, so what we need to make sure is that there is no problem 00:31:48.251 --> 00:31:51.352 in the skin contact within the 3D- 00:31:51.352 --> 00:31:54.830 printed part and the patient. 00:31:55.249 --> 00:32:00.444 But even if we show this, and this is something that can be accessed by anyone, 00:32:00.444 --> 00:32:04.802 we still always ask our customers 00:32:04.802 --> 00:32:08.992 or the end-user or the printing partner 00:32:08.992 --> 00:32:13.601 like Materialise here to make sure as well to do a testing on their site 00:32:13.726 --> 00:32:15.319 after producing the part. 00:32:15.319 --> 00:32:20.305 So this is what we have tested on our side, but we always want to have the extra 00:32:20.305 --> 00:32:24.830 validation from the end-user to make sure that these parts are going to be compliant 00:32:26.213 --> 00:32:28.643 for the use of the patient. 00:32:28.643 --> 00:32:32.623 But apart from this I think that Radhika mentioned already most of the things, but this is 00:32:32.623 --> 00:32:37.149 again where it is very important to have the different players working together. 00:32:37.400 --> 00:32:39.076 We have a material provider. 00:32:39.076 --> 00:32:40.375 We have a printing company. 00:32:40.375 --> 00:32:45.612 Then we have the company that is going to be doing the printing process 00:32:46.073 --> 00:32:50.054 and potentially post-processing afterwards, and here's 00:32:50.096 --> 00:32:53.783 where it's going to be very important that everyone is well coordinated together 00:32:54.202 --> 00:32:57.219 to collaborate and get a good outcome here. 00:32:57.596 --> 00:33:01.367 And here I think, Radhika, you wanted to mention and to talk about 00:33:01.660 --> 00:33:04.635 how important it is to have this cross- industry collaboration, right? 00:33:06.101 --> 00:33:07.107 Yes, David, I think that's 00:33:07.107 --> 00:33:10.124 exactly right. You see by now how 00:33:10.124 --> 00:33:13.141 many different players are involved in determining 00:33:13.141 --> 00:33:16.618 the eventual quality of a printed product, 00:33:17.037 --> 00:33:20.557 which in medtech, is really critical to the success of this technology 00:33:20.557 --> 00:33:24.118 in the industry and from our side, I would like 00:33:24.454 --> 00:33:28.895 to say that we're very committed to helping the industry to scale up. As we can see from HP 00:33:28.895 --> 00:33:32.959 as well, the industry of 3D printing as a whole 00:33:33.504 --> 00:33:37.820 really takes this at heart. Here, we're looking at an example of 00:33:37.820 --> 00:33:42.345 how we've done this in the aerospace industry. A few years ago, 00:33:42.345 --> 00:33:47.205 we started to recognize this challenge that design organizations for 00:33:47.205 --> 00:33:53.071 aerospace had the burden of certification on their side, but in order to certify or 00:33:53.155 --> 00:33:57.974 qualify new applications, theu needed data on how printed parts actually perform. 00:33:59.398 --> 00:34:01.326 In other words, performance data. 00:34:01.326 --> 00:34:04.636 How much is the variation in terms of dimensional accuracy? 00:34:05.348 --> 00:34:08.407 On a good day versus a bad day, how much variability do you see? 00:34:08.910 --> 00:34:13.896 So what we did from Materialise was to literally log that data so printed. 00:34:13.896 --> 00:34:18.505 Check tensile bar in each build, log the process so that we are doing exactly the same thing 00:34:18.505 --> 00:34:23.281 from time to time. And then to measure exactly what results we get. 00:34:23.616 --> 00:34:27.136 We make that data available to design organizations in aerospace, 00:34:27.471 --> 00:34:31.577 and said this is the variability that you can expect. Depending on this, what 00:34:31.661 --> 00:34:34.636 sort of applications can you qualify, 00:34:35.307 --> 00:34:36.773 so what sort of design parameters 00:34:36.773 --> 00:34:38.575 can you push? 00:34:38.575 --> 00:34:41.089 This really took a lot of openness 00:34:41.089 --> 00:34:45.321 from different players in aerospace to make that happen, and now we see 00:34:45.321 --> 00:34:49.427 more and more applications being qualified for 3D printing. Similarly, 00:34:49.636 --> 00:34:55.293 in medtech, I believe we need this sort of open collaboration, and to those of you 00:34:55.293 --> 00:35:00.907 on the call who have different expectations of quality, we would really love 00:35:00.907 --> 00:35:03.924 to hear about them so either feel free to raise them at 00:35:03.924 --> 00:35:07.989 the end of this session or also always feel free to get in touch with us 00:35:07.989 --> 00:35:10.628 afterwards. Similar to 00:35:11.592 --> 00:35:13.645 this discussion around quality, 00:35:13.645 --> 00:35:16.662 I would say that we also see similar 00:35:16.662 --> 00:35:21.019 tendencies towards collaboration in business models. And there I think O&P serves as a 00:35:21.271 --> 00:35:25.000 very interesting application where different players in 00:35:25.000 --> 00:35:28.436 3D printing are coming together to make mass customization happen. 00:35:29.064 --> 00:35:33.464 On that David, can you give us an example of how that workflow really looks like? 00:35:34.092 --> 00:35:36.816 Sure, so indeed as you were saying, collaboration 00:35:36.816 --> 00:35:39.833 is extremely important when it comes to O&P. 00:35:40.335 --> 00:35:44.148 The O&P workflow is is a very interesting one to look at 00:35:44.483 --> 00:35:48.171 because when we are coming from the traditional process where we have 00:35:48.590 --> 00:35:52.193 a patient in front of us, where we might be doing a casting or molding, 00:35:52.528 --> 00:35:53.701 we're going to be doing different 00:35:53.701 --> 00:35:56.970 things to get the exact measures from that patient to 00:35:57.472 --> 00:36:02.584 create this device. Whenever we move to additive manufacturing, it also 00:36:02.626 --> 00:36:08.073 comes with what we call the digital workflow. The digital workflow works though different 00:36:08.073 --> 00:36:11.090 steps that start with the clinician 00:36:11.216 --> 00:36:14.232 together with the patient doing a scan. 00:36:14.316 --> 00:36:16.663 This scan can be done in different ways. 00:36:16.663 --> 00:36:19.051 It can be done using a simple phone. 00:36:19.051 --> 00:36:24.079 It can be done using a tablet or it can be done using a dedicated scanner device 00:36:24.079 --> 00:36:27.640 depending on the level of resolution that you're going to need or the device that you 00:36:27.640 --> 00:36:28.856 feel more comfortable with. 00:36:29.945 --> 00:36:30.825 We're going to be doing the 00:36:30.825 --> 00:36:34.638 scan of the part of the body that we need 00:36:34.638 --> 00:36:37.613 to have data on to then produce the part. 00:36:38.409 --> 00:36:41.174 This scan is then going to be 00:36:41.174 --> 00:36:43.730 moved to 00:36:43.730 --> 00:36:44.736 a software. 00:36:44.736 --> 00:36:48.255 But what we're going to do is modify it or 00:36:49.009 --> 00:36:53.535 rectify is the way we call it. This rectified scan, what we do in the end 00:36:53.535 --> 00:36:56.929 is making sure that we just keep the parts of the scan that we're interested in. 00:36:56.929 --> 00:37:00.071 For example, let's imagine back to insoles. If I 00:37:00.071 --> 00:37:03.046 scan a full leg and a foot to design an insole, 00:37:03.591 --> 00:37:04.764 I might not need to- 00:37:04.764 --> 00:37:09.750 I do not need the leg to design the part because in the end, it will just need to sit against the foot, 00:37:10.127 --> 00:37:13.060 so I can remove from that scan the whole part of the 00:37:13.060 --> 00:37:16.370 leg because it's going to make my processing time a bit slower and 00:37:16.831 --> 00:37:19.429 it my scan is really going to be optimized 00:37:19.429 --> 00:37:23.661 if I have only that part that I need. So I will keep the foot, but 00:37:23.661 --> 00:37:27.432 then making sure that all the surfaces of the foot are smooth. 00:37:27.474 --> 00:37:30.449 Sometimes the scan is done a bit too fast or a bit too slow 00:37:30.658 --> 00:37:33.423 or there are different things that can potentially affect the scan, 00:37:33.423 --> 00:37:34.848 and this is something that 00:37:34.848 --> 00:37:38.619 you learn through time and some software today are actually already telling you, hey, 00:37:38.829 --> 00:37:41.301 this is a good scan or this is not a good scan. 00:37:41.301 --> 00:37:44.317 So it also helps you, giving you immediate feedback on how you're doing. 00:37:44.904 --> 00:37:47.334 But, through this, we can get to a good shape. 00:37:47.334 --> 00:37:49.890 That then we can use the go to the next step. 00:37:49.890 --> 00:37:53.829 Where we will generate the design of the part that 00:37:53.829 --> 00:37:58.773 we're going to do. This is where, again, using specific software, we will have 00:37:58.899 --> 00:38:04.010 the foot where we will say listen, I want to create an insole that adapts to this foot. 00:38:04.555 --> 00:38:06.943 The insole will be, somehow, 00:38:07.907 --> 00:38:08.745 it can be 00:38:08.745 --> 00:38:11.930 automatically generated to adapt to the shape of the foot. 00:38:12.474 --> 00:38:15.491 And this is where, together with the input from the clinician, 00:38:15.826 --> 00:38:19.011 we can make sure to input some little parameters that we have. 00:38:19.136 --> 00:38:23.075 Where, for example, we can say we need a little bit more of a heel. 00:38:23.243 --> 00:38:27.223 Or, there is a certain level of pronation from the patient, so we need to compensate on 00:38:27.265 --> 00:38:30.198 one side or the other side and these are different inputs that we 00:38:30.198 --> 00:38:33.299 can put in the tool to do that design of that final part. 00:38:34.430 --> 00:38:37.195 Once we have this final part design, 00:38:37.195 --> 00:38:40.841 this is where we would move to the printing process, this would move to the MJF 00:38:40.966 --> 00:38:43.983 printer where we could get this part. 00:38:44.360 --> 00:38:47.922 We call this a raw part at the exit of the process and this is where, 00:38:47.964 --> 00:38:52.447 at the end, we will do most of the time, is some kind of post-processing where we 00:38:52.573 --> 00:38:55.966 want to have potentially the part a bit smoother. 00:38:56.511 --> 00:38:59.528 We might want to also apply color 00:38:59.570 --> 00:39:02.629 and other potential surface treatments that we might 00:39:02.629 --> 00:39:06.106 want for this part, and then for certain of these parts 00:39:06.567 --> 00:39:10.296 there might be a last step which will be an assembly phase. 00:39:11.637 --> 00:39:14.151 And after this, that's where we would have 00:39:14.151 --> 00:39:18.802 our final part ready to use, ready to give to the patient for the treatment to start. 00:39:20.394 --> 00:39:23.076 To make this digital ecosystem work, 00:39:23.076 --> 00:39:27.559 this is where, on the next slide, what we will see is a lot of different 00:39:28.271 --> 00:39:31.246 partners or companies that already exist today. 00:39:31.498 --> 00:39:34.221 Again, this slide might look a bit overwhelming. 00:39:34.221 --> 00:39:37.992 I just want you to stick with one 00:39:38.034 --> 00:39:42.266 message, which is that at the top, you will still see the same steps that we mentioned, 00:39:42.685 --> 00:39:47.084 the scanning, modifying the scan, generate the design, printing, and post-processing. 00:39:47.755 --> 00:39:50.185 And this is where all of the different logos that you will see 00:39:50.185 --> 00:39:53.788 here are different companies, software companies and 00:39:54.417 --> 00:39:57.727 material companies for some for the printing part and the post-processing, 00:39:59.571 --> 00:40:02.043 you will see software that already have capabilities 00:40:02.043 --> 00:40:05.772 to help automate or generate some of those designs. 00:40:06.065 --> 00:40:07.490 So we're not starting from zero. 00:40:07.490 --> 00:40:11.177 There is a lot of expertise in the field. There are a lot of players in the field. 00:40:11.177 --> 00:40:14.864 Some of them are better for some applications, some better for others. 00:40:15.116 --> 00:40:18.761 There are different levels of expertise or it might depend on other variables that you 00:40:18.761 --> 00:40:23.663 might consider, but there is a very big ecosystem out there where from our site in 00:40:23.663 --> 00:40:28.565 HP we can also help to guide you in choosing the best partner 00:40:28.943 --> 00:40:32.546 for your application. And this is where we can have conversations and we're very 00:40:32.546 --> 00:40:36.443 happy to walk you through the process and connect you to those different providers that can 00:40:37.658 --> 00:40:40.549 make the journey to make your 00:40:40.549 --> 00:40:43.566 3D-printed parts successful in the market. 00:40:43.817 --> 00:40:45.661 Now we wanted to move into some use 00:40:45.661 --> 00:40:48.677 cases that we believe are relevant for this, looking at 00:40:48.677 --> 00:40:52.448 O&P on one side, but also some other medical applications. 00:40:52.826 --> 00:40:56.303 And for this first example, I want to get one where in, again, 00:40:56.387 --> 00:40:59.949 in this sector ecosystem map, you can see Materialise here as well. 00:41:00.326 --> 00:41:03.594 So we wanted to go into an example where the Materialise 00:41:03.678 --> 00:41:06.988 software is used for the creation of custom insoles. 00:41:07.700 --> 00:41:11.806 So if we go to the next slide, maybe Radhika, you being from 00:41:12.141 --> 00:41:15.912 Materialise, it would to be great to have you explain what is happening here. 00:41:17.463 --> 00:41:19.055 Good. Thanks, David. 00:41:19.055 --> 00:41:23.454 We're looking here at the workflow that is use by Materialise Motion, 00:41:23.790 --> 00:41:28.818 a subsidiary of Materialise that focuses on the creation of patient- 00:41:28.818 --> 00:41:34.097 specific insoles. You're seeing here a patient walking on a dynamic foot scan device. 00:41:35.270 --> 00:41:36.276 So we 00:41:36.276 --> 00:41:39.544 use pressure plates to analyze the gait of a person while they walk. 00:41:39.921 --> 00:41:42.770 So you can see exactly where the pressure points are, 00:41:42.770 --> 00:41:46.374 where a person needs more support. A podiatrist 00:41:46.374 --> 00:41:49.432 can use the front-end software that Materialise 00:41:50.606 --> 00:41:52.910 designs to really design the 00:41:52.910 --> 00:41:55.885 insole based around the anatomy of the patient. 00:41:56.095 --> 00:42:00.201 Ultimately then those insoles are also produced at Materialise. 00:42:00.745 --> 00:42:04.223 So what you're seeing here is the result of 00:42:05.187 --> 00:42:09.125 a few different complex sets of software that is a storefront, 00:42:09.628 --> 00:42:14.447 which is used by the podiatrist to customize the insole to the patient. 00:42:14.782 --> 00:42:17.799 Then there is an design automation that 00:42:17.924 --> 00:42:22.785 actually designs the insoles and makes them ready for print. And then an order automation that sense the 00:42:22.785 --> 00:42:26.807 product into production at Materialise, ultimately resulting in 00:42:27.226 --> 00:42:29.405 3D-printed, personalized insoles. 00:42:29.405 --> 00:42:31.374 Thank you very much. 00:42:31.374 --> 00:42:36.151 This is a great example of how one of those software solutions would work. 00:42:36.696 --> 00:42:39.377 I have here another use case that I can share and I have the 00:42:39.377 --> 00:42:40.969 part here with me. 00:42:40.969 --> 00:42:42.394 So this is a prosthetic socket 00:42:42.394 --> 00:42:45.327 that is for lower limb. 00:42:45.327 --> 00:42:48.553 It is being dan by a company called Quorum based in the US. 00:42:49.308 --> 00:42:53.833 What this company has done is through additive manufacturing and MJF, 00:42:54.336 --> 00:42:57.897 what they have designed is a prosthetic socket that 00:42:58.400 --> 00:43:01.040 is enhancing the fit 00:43:01.040 --> 00:43:04.056 and the lightweight and the comfort for the patient. 00:43:04.685 --> 00:43:07.827 If you look at the part here, you will see inside that there is 00:43:07.827 --> 00:43:11.682 a part done in TPU. It's more flexible 00:43:13.023 --> 00:43:14.908 to get the better fit of the patient, 00:43:14.908 --> 00:43:18.470 to also get the better sensation and the fact that it has holes around 00:43:18.805 --> 00:43:22.367 also help to make the device more breathable and lighter at the same time, 00:43:22.450 --> 00:43:25.509 which also contribute to enhancing the comfort of the patient. 00:43:26.431 --> 00:43:28.149 And what this company has also done, 00:43:28.149 --> 00:43:31.291 so this prosthetic socket is designed 00:43:31.710 --> 00:43:34.685 for one very specific patient, so it's a personalized one. 00:43:35.062 --> 00:43:37.953 But sometimes you might want to have the last few tweaks 00:43:37.953 --> 00:43:40.803 at the moment of the fitting, which would come at the end 00:43:40.803 --> 00:43:42.562 when you deliver the part. 00:43:42.562 --> 00:43:44.280 This is where they have incorporated 00:43:44.280 --> 00:43:47.884 these little parts that you can also see 00:43:48.973 --> 00:43:51.990 inside, which are kind of 00:43:52.325 --> 00:43:57.730 adjusting the pressure around the limb and we have this mechanism here where we 00:43:57.730 --> 00:44:01.795 can tighten it or loosen it to make sure that the fit is 00:44:01.878 --> 00:44:05.105 as good as possible for the patient, but as comfortable as possible. 00:44:05.691 --> 00:44:08.834 So this is where Quorum had the 00:44:09.881 --> 00:44:11.599 great idea of combining 00:44:11.599 --> 00:44:15.705 different materials. Other HP customers also do that, combining 00:44:16.166 --> 00:44:19.351 the softer part on the inside for the fit and the comfort but 00:44:19.895 --> 00:44:24.379 keeping an outer shell that is more rigid, done in this case with PA 12, 00:44:24.840 --> 00:44:27.479 to make sure that it also meets the mechanical properties of this 00:44:27.479 --> 00:44:30.622 part that in the end is going to be carrying the weight of the patient 00:44:30.622 --> 00:44:34.644 when the patient is going to be walking, so this is also a great compromise between 00:44:35.105 --> 00:44:37.619 comfort, lightweight, functionality, 00:44:37.619 --> 00:44:41.264 and performance that we can have in these kind of devices. And 00:44:41.264 --> 00:44:45.035 this is where, again, additive manufacturing can help in bringing those 00:44:45.035 --> 00:44:50.189 ideas to life, bringing new designs that we had never seen before, to get an 00:44:50.189 --> 00:44:53.373 application that will get the best out of it and the best 00:44:53.667 --> 00:44:56.642 use for the patient. 00:44:56.642 --> 00:45:00.413 So I think these were the three examples that I wanted to show 00:45:00.664 --> 00:45:04.435 O&P. I think, Radhika, you have a couple more examples that you wanted to share. 00:45:04.728 --> 00:45:05.943 So, we move to the next slide, please. 00:45:08.206 --> 00:45:10.217 Thanks, David. I did want to 00:45:10.217 --> 00:45:14.282 highlight a few examples that look at different drivers of 3D printing. 00:45:14.282 --> 00:45:17.089 Now with O&P, we have a view of how 3D printing 00:45:17.089 --> 00:45:20.944 enables mass customization. In machinery and equipment, though, 00:45:21.153 --> 00:45:26.139 we also see 3D printing being used for its design complexity benefits. I believe 00:45:26.139 --> 00:45:30.413 when we did the roundup of why you're looking at 3D printing, a couple of you pointed out 00:45:30.539 --> 00:45:34.687 design complexity as your driver. Here we have an example from a customer 00:45:34.687 --> 00:45:38.542 of ours that's really using it to great economic advantage. 00:45:38.542 --> 00:45:42.229 So Ossila is a manufacturer of spectrometers. 00:45:42.229 --> 00:45:46.712 They use 3D printing to produce these housings that you see at the back 00:45:46.712 --> 00:45:48.304 over there. 00:45:48.304 --> 00:45:52.494 It's a device that traditionally would have involved a lot of different components, 00:45:52.955 --> 00:45:57.187 and this device needs to be light-tight, which means two things: that the 00:45:57.187 --> 00:46:02.006 materials need to be well chosen and the finish needs to be well chosen, that no light can escape, 00:46:03.556 --> 00:46:05.400 and also 00:46:05.400 --> 00:46:08.249 that, in addition to the choice of the material being right, 00:46:08.249 --> 00:46:11.266 that assembly needs to be quite precise. 00:46:11.307 --> 00:46:14.659 Now in a traditional setup where you have a lot of moving components and 00:46:14.659 --> 00:46:18.095 where assembly is manual, that takes a lot of time. 00:46:18.724 --> 00:46:22.956 This was the main driver for Ossila to look at 3D printing. It was about efficiency. 00:46:23.249 --> 00:46:28.026 Can we combine a few of these components into fewer components so assembly is faster? 00:46:28.528 --> 00:46:33.514 By using MJF, they were able to use a PA 12 that is higher density than 00:46:33.724 --> 00:46:38.961 the same material in SLS, and by using clever design for additive manufacturing, 00:46:39.339 --> 00:46:44.157 they were able to cut down their assembly so the total number of components was halved, 00:46:44.492 --> 00:46:48.263 which then resulted in a final product assembly time of 30 minutes, 00:46:48.682 --> 00:46:51.657 which is 4 – 5 times faster than the original. 00:46:52.034 --> 00:46:56.518 I think this is the case that can really inspire across machinery and equipment, 00:46:57.062 --> 00:47:00.037 not even exclusively medtech. 00:47:00.414 --> 00:47:02.635 On the next slide, we see an example 00:47:02.635 --> 00:47:07.412 that focuses on time-to- market, which was also a factor that 00:47:07.831 --> 00:47:11.979 people were picking up in the drivers for 3D printing and I believe that come out near 00:47:12.021 --> 00:47:15.331 the top in terms of why we look at this technology. 00:47:15.750 --> 00:47:18.389 Gogoa was a company that was a scale-up 00:47:18.389 --> 00:47:22.035 in 2015, I believe, and within 3 years 00:47:22.077 --> 00:47:25.051 they were the first scale-up to get 00:47:25.051 --> 00:47:28.068 a CE marking for an exoskeleton in Europe. 00:47:28.110 --> 00:47:30.876 So what you see here is a rehabilitation 00:47:30.876 --> 00:47:34.940 aid. It's an exoskeleton that helps patients relearn how to walk 00:47:35.526 --> 00:47:38.124 and almost all of the parts 00:47:38.124 --> 00:47:42.356 that you see in the exoskeleton externally are 3D printed. 00:47:42.985 --> 00:47:46.504 Nearly all of them with MJF. So you see that there's 00:47:46.504 --> 00:47:49.982 fifteen parts in each exoskeleton that are 3D printed in PA 12 00:47:50.652 --> 00:47:53.837 and on top of that, the sole at the bottom of the foot is printed 00:47:53.879 --> 00:47:55.052 in TPU. 00:47:55.052 --> 00:47:59.158 There's also a few components in PA 11, I believe. 00:47:59.577 --> 00:48:03.474 So altogether this device really shows how 00:48:03.809 --> 00:48:08.795 with iterative design, a scale-up can bring a product to market quickly 00:48:09.172 --> 00:48:12.524 by being agile, by being able to iterate their product 00:48:12.901 --> 00:48:17.007 faster and ultimately go to market with the same technology that 00:48:17.007 --> 00:48:20.611 they were using for prototyping. For niche products 00:48:20.737 --> 00:48:23.963 where you're looking to produce a few 00:48:23.963 --> 00:48:27.189 hundreds to even a few thousands or even tens of thousands a year, 00:48:27.860 --> 00:48:31.631 3D printing can be an interesting end-part production technology. 00:48:33.055 --> 00:48:35.443 Now, with all of that seen, 00:48:35.443 --> 00:48:38.083 I believe that we have established how 00:48:38.083 --> 00:48:41.100 3D printing can be an interesting way to 00:48:41.351 --> 00:48:45.039 boost your product development, which is really the main message, 00:48:45.039 --> 00:48:49.773 I would say. From both HP's side as well as Materialise's. 00:49:46.045 --> 00:49:47.176 From Materialise, 00:49:47.176 --> 00:49:51.618 we are here to help you in all stages of your product development cycle. 00:49:52.581 --> 00:49:55.472 We have teams that support in applications spotting, so the 00:49:55.472 --> 00:49:59.327 discovery end, which is where you're looking for what sort of parts does 00:49:59.369 --> 00:50:01.716 it make sense to 3D print? 00:50:01.716 --> 00:50:06.241 We have design and engineering teams that can consult with you on feasibility, 00:50:06.702 --> 00:50:10.808 so identifying the right applications that make sense to 3D 00:50:11.353 --> 00:50:14.411 print from a feasibility perspective, to also helping you 00:50:15.626 --> 00:50:18.643 develop the business cases for those, which is really 00:50:18.978 --> 00:50:22.205 where a lot of the success of 3D printing is, 00:50:23.755 --> 00:50:26.772 let's say, it's a make or break moment for the success of 3D printing. 00:50:27.233 --> 00:50:32.596 And then onwards to eventually the manufacturing of the technology which 00:50:33.811 --> 00:50:34.565 as a series 00:50:34.565 --> 00:50:38.336 manufacturing service provider is what we specialize in 00:50:38.755 --> 00:50:42.233 under both ISO 9001 and ISO 13485, 00:50:42.610 --> 00:50:46.297 depending on the exact needs of your application. 00:50:46.800 --> 00:50:50.487 So with that, I believe that we come to the end of 00:50:50.487 --> 00:50:54.426 our presentation. I don't want to rush us out, but I do want to hear 00:50:54.426 --> 00:50:55.096 from you 00:50:55.096 --> 00:50:59.663 the audience on any questions that you may have. So, just a few quick facts again 00:50:59.705 --> 00:51:04.230 on who Materialise is. We have a division that focuses on patient- 00:51:04.230 --> 00:51:08.253 specific care, which helps over 55,000 patients a year. 00:51:09.719 --> 00:51:11.395 But even in standardized 00:51:11.395 --> 00:51:14.580 applications such as what I believe most of you are active in, 00:51:15.124 --> 00:51:18.476 last year we produced over 150 thousand parts 00:51:18.812 --> 00:51:21.535 for medical equipment and machinery per year, 00:51:21.535 --> 00:51:24.552 and so with that I hand it over to you 00:51:24.552 --> 00:51:27.778 the audience. We're curious to hear your thoughts. 00:51:29.915 --> 00:51:31.968 So, over to you, Frank. 00:51:33.225 --> 00:51:36.912 Thanks, Radhika and yeah, I have 00:51:36.912 --> 00:51:40.348 seen some questions flying in and in the meantime I will also share 00:51:40.683 --> 00:51:43.658 the link that I was pointing out, so 00:51:43.784 --> 00:51:46.591 everybody should have gotten it 00:51:46.591 --> 00:51:49.776 through the chat. If not, just have a quick look in the chat. 00:51:49.776 --> 00:51:52.541 You will see it there. 00:51:52.541 --> 00:51:55.558 Yeah, I will just read out the questions and 00:51:56.228 --> 00:51:58.868 either one of you will answer to that. 00:51:58.868 --> 00:52:01.591 First one: AM technologies in terms of 00:52:01.591 --> 00:52:04.818 cost-efficiency and scalability for orthotics and prosthetics, 00:52:05.488 --> 00:52:08.463 I think there's a word missing, what is the, 00:52:08.798 --> 00:52:12.611 what role does AM technology play in terms of cost-efficiency 00:52:12.611 --> 00:52:15.586 for orthotics and prosthetics? 00:52:16.675 --> 00:52:18.519 So I can take 00:52:18.519 --> 00:52:21.536 this one and, Radhika, feel free to do complement. 00:52:21.620 --> 00:52:22.835 Here is where you have, 00:52:22.835 --> 00:52:23.882 you have a lot of different 00:52:23.882 --> 00:52:27.737 technologies in the additive manufacturing space, and the people who are in it 00:52:28.072 --> 00:52:31.173 I'm sure already have experience and have investigated different of them 00:52:31.718 --> 00:52:33.687 and it all comes to, in the end, 00:52:35.195 --> 00:52:38.003 the quality that you want, 00:52:38.003 --> 00:52:40.852 the volumes that you're managing, 00:52:40.852 --> 00:52:43.450 and also the type of devices that you want to do. 00:52:43.450 --> 00:52:46.718 So, whenever you want to continue scaling, 00:52:46.718 --> 00:52:51.159 MJF is a great solution when you want to have products at scale. 00:52:51.620 --> 00:52:54.008 You have a lot of devices. 00:52:54.008 --> 00:52:57.486 You can have a very, very portfolio of devices as well because the good thing 00:52:57.905 --> 00:53:02.053 of MJF is that you can nest a lot of very different parts into the same 00:53:02.053 --> 00:53:05.824 build, and this is not going to affect the different parts or the quality 00:53:05.824 --> 00:53:06.285 or anything. 00:53:06.285 --> 00:53:09.469 So you can be printing an insole next to 00:53:10.307 --> 00:53:12.612 a cranial helmet next to a prosthetic socket. 00:53:12.612 --> 00:53:15.210 This is something that gives you a lot of flexibility. 00:53:15.210 --> 00:53:18.185 If you have a lot of different parts that you are managing 00:53:18.729 --> 00:53:21.160 and this is how in this way, 00:53:21.160 --> 00:53:23.338 when you optimize the build, this is actually what we, 00:53:24.302 --> 00:53:26.481 from HP, we recommend to optimize the build, the more you put in 00:53:26.481 --> 00:53:31.383 there, the most you're going to be cost-efficient, and this is the best way as well 00:53:31.383 --> 00:53:34.777 to approach it. One of the things that we also recommend, if volumes are very low, 00:53:35.196 --> 00:53:38.883 you might want to start with another technology or you can also 00:53:39.177 --> 00:53:44.163 reach out and talk to a contract manufacturer from HP, which would be, 00:53:44.163 --> 00:53:48.101 for example, Materialise here, who have a lot of experience in these kind of devices 00:53:48.520 --> 00:53:50.154 and they can be the people who can help 00:53:50.154 --> 00:53:54.009 you get to the point to slowly scale with your first prototypes, 00:53:54.009 --> 00:53:57.654 your first parts and deliver knowing that you're 00:53:57.822 --> 00:54:00.755 producing for a company that has experience and is 00:54:00.755 --> 00:54:03.939 certified for medical devices. 00:54:04.275 --> 00:54:04.861 So these are 00:54:04.861 --> 00:54:07.962 different approaches that you can follow. 00:54:08.046 --> 00:54:09.596 If you're a small clinic, 00:54:09.596 --> 00:54:13.032 just getting started, and you just want to have a few parts to play with, 00:54:13.325 --> 00:54:16.258 then you potentially have other technologies that can be more interesting for 00:54:16.258 --> 00:54:20.783 you because they might be cheaper to afford as well and you don't have today the 00:54:20.825 --> 00:54:25.057 volume that potentially would justify using a more industrial printer like 00:54:25.267 --> 00:54:25.686 MJF. 00:54:27.697 --> 00:54:28.786 Not sure, Radhika, if you have 00:54:28.786 --> 00:54:31.803 anything to add to do that. 00:54:31.803 --> 00:54:34.107 Yeah, David, I believe you really covered everything. 00:54:34.107 --> 00:54:38.884 I think that for an O&P company being able to prove scalability often 00:54:39.094 --> 00:54:43.828 comes down to having the right partners and the right business model, 00:54:44.122 --> 00:54:47.809 which starting small is always a good approach, 00:54:47.809 --> 00:54:52.292 let's say. If you have one product line that has niche products or where 00:54:52.418 --> 00:54:55.602 mass customization can make the most difference, 00:54:56.105 --> 00:55:01.259 that's the one where you would start. In terms of consulting on viability or 00:55:01.301 --> 00:55:05.742 feasibility, we have expert consulting teams that do that, so. 00:55:05.784 --> 00:55:08.465 please reach out to us if we can help. 00:55:08.465 --> 00:55:12.111 All right, thank you both, we have five minutes left, so two more questions 00:55:12.111 --> 00:55:14.038 I think at least. 00:55:14.038 --> 00:55:18.647 What advice would you give to smaller medtech companies who lack resources for establishing 00:55:18.647 --> 00:55:22.628 partnerships, but want to adopt AM technologies effectively? 00:55:24.387 --> 00:55:27.362 I think this is what we just mentioned right now, right? 00:55:27.572 --> 00:55:30.002 And it is what, 00:55:30.002 --> 00:55:32.055 and you reiterated it. Make sure 00:55:32.055 --> 00:55:35.826 that you partner with people who already have the technology that you might 00:55:35.826 --> 00:55:39.974 want to use. They can provide samples to you for you to be more convinced about the 00:55:40.184 --> 00:55:43.745 part quality or the type of parts that you're looking for. 00:55:44.332 --> 00:55:47.600 But also this is the best way to get started. 00:55:48.187 --> 00:55:51.622 Don't get lost into how to operate or start with the hardware. 00:55:52.041 --> 00:55:55.352 Maybe start with someone who has the experience, has the knowledge, and has the 00:55:55.352 --> 00:55:58.662 device already and then, potentially down the road, 00:55:58.662 --> 00:55:59.290 if you see 00:55:59.290 --> 00:56:02.852 that it makes sense, then you can start think about bringing the technology in-house. 00:56:03.187 --> 00:56:07.125 But at the beginning, we always recommend to go through a partner that has 00:56:07.125 --> 00:56:11.148 the experience that can help you there as we mentioned again before, like Materialise 00:56:11.315 --> 00:56:11.818 in this case. 00:56:13.829 --> 00:56:14.667 Exactly, and I think 00:56:14.667 --> 00:56:19.151 regulatory concerns really can be a bit of a blocker for smaller 00:56:19.612 --> 00:56:22.922 medtech start-ups and scale-ups, especially. So in those cases 00:56:22.922 --> 00:56:23.466 I think that we 00:56:23.466 --> 00:56:27.363 can take some inspiration from what other industries have done. In aerospace, 00:56:27.363 --> 00:56:30.925 for example, where we saw that the early success stories all came from low- 00:56:30.925 --> 00:56:34.863 criticality applications. Similarly, in medtech, I think that 00:56:35.240 --> 00:56:39.263 for start-ups and scale-ups that struggle with the regulatory aspect especially, 00:56:39.975 --> 00:56:44.291 take a look at applications where the regulatory burden is lower. 00:56:44.710 --> 00:56:48.187 And if that can help you develop your confidence in the technology, 00:56:49.025 --> 00:56:52.336 that can be the right way to step up your game and to develop 00:56:52.503 --> 00:56:55.813 the knowledge that you need to make sure that your product is compliant. 00:56:59.165 --> 00:57:00.380 Okay, thank you. 00:57:00.380 --> 00:57:05.199 I think also the next one has been slightly touched on with your answers already. 00:57:05.199 --> 00:57:09.137 What are the key factors medtech companies should consider when planning to scale end-part 00:57:09.179 --> 00:57:12.364 production while ensuring consistency, part quality, and compliance? 00:57:12.992 --> 00:57:13.411 Radhika? 00:57:15.213 --> 00:57:16.679 I think you're right, 00:57:16.679 --> 00:57:20.283 that this is a topic that comes back over and over, and I would say that it 00:57:21.498 --> 00:57:24.640 mainly boils down to the correct understanding of 00:57:24.640 --> 00:57:28.537 what quality means for you, which is absolutely a 00:57:28.537 --> 00:57:33.188 case-by-case question that quality for one kind of product, for one kind of company 00:57:34.152 --> 00:57:37.504 could have completely different metrics for success compared to another. 00:57:37.881 --> 00:57:40.353 So what exactly does quality mean for your product? 00:57:40.353 --> 00:57:41.987 Is it dimensional accuracy? 00:57:41.987 --> 00:57:44.333 Is it cleanability? How would you measure that? 00:57:44.333 --> 00:57:49.152 Is it about surface roughness, for example, or do you measure powder residue? 00:57:49.571 --> 00:57:53.342 So what it really comes down to is making sure that we're talking 00:57:53.342 --> 00:57:57.029 about measuring exactly the same criteria for success. 00:57:57.490 --> 00:58:00.046 And so what we do for 00:58:00.046 --> 00:58:03.901 series manufacturing projects is to have a very intensive onboarding 00:58:04.278 --> 00:58:08.049 to exactly understand what your criteria for success and scalability are. 00:58:10.563 --> 00:58:13.580 Okay, I think the last question 00:58:13.663 --> 00:58:16.680 and then I will just close it here. 00:58:17.141 --> 00:58:19.027 I want to get started in the 3D printing journey 00:58:19.027 --> 00:58:22.630 for medical devices, but I don't know how to get started or whom to contact. 00:58:22.630 --> 00:58:26.192 I think you mentioned it, Radhika, already in your presentation and you as well, 00:58:27.323 --> 00:58:30.088 David, but maybe it's worthwhile to 00:58:30.088 --> 00:58:34.236 drop it here in the chat so we can share or we share later with the recording 00:58:34.236 --> 00:58:37.253 afterwards. 00:58:38.007 --> 00:58:39.306 Yes, I would say that 00:58:39.306 --> 00:58:43.161 both David and I are very happy to help with this question. 00:58:43.161 --> 00:58:48.063 So we got one contact address already on the slide here. 00:58:48.566 --> 00:58:51.834 We will also put in our contact details afterwards as a 00:58:51.834 --> 00:58:55.312 follow up Frank, if I'm not mistaken we can just put it in the chat 00:58:55.312 --> 00:59:00.759 perhaps. A good place to start with is identifying the right applications 00:59:00.969 --> 00:59:03.608 for 3D printing. 00:59:03.608 --> 00:59:05.913 I'm sure everybody you see on the screen 00:59:05.913 --> 00:59:07.212 here today is happy to help. 00:59:09.516 --> 00:59:11.276 All right, 00:59:11.276 --> 00:59:14.251 anything more from you both or 00:59:15.340 --> 00:59:18.483 otherwise we can close it here. I also want to give you the words still. 00:59:19.782 --> 00:59:22.421 Yeah, the only thing I wanted to say from my side is again 00:59:22.421 --> 00:59:26.695 thank you very much for inviting us to this session, Frank and Radhika. 00:59:26.695 --> 00:59:30.173 Very happy to share the stage with the two of you 00:59:30.634 --> 00:59:35.536 and again any question you have any exploration you want to do, 00:59:36.039 --> 00:59:38.846 just a reminder again of what we've said a 00:59:38.846 --> 00:59:43.413 few times. Feel free to reach out. Reach out to Radhika, reach out to myself. 00:59:43.413 --> 00:59:47.855 You will have email contacts or look for us on LinkedIn or whatever works for you. 00:59:48.357 --> 00:59:51.123 Look for us, we will help you in making sure that you can 00:59:51.123 --> 00:59:54.559 start in your journey or continue scaling in the journey that 00:59:54.559 --> 00:59:58.288 you might have already started into additive manufacturing for medtech. 00:59:58.288 --> 01:00:04.154 We are just one email away or one ping a way to help you there. 01:00:06.333 --> 01:00:09.307 Thanks very much for joining us, David. I really appreciate the 01:00:09.307 --> 01:00:12.282 insight that you've shown into the orthotics and prosthetics, especially. 01:00:14.922 --> 01:00:17.143 Thank you both very much for the insights 01:00:17.143 --> 01:00:18.819 we got here 01:00:18.819 --> 01:00:22.255 as an audience. We need to end the session for today 01:00:22.255 --> 01:00:25.271 and as we said in the beginning, we will follow up on 01:00:25.690 --> 01:00:28.707 some more complex questions after the presentation 01:00:29.084 --> 01:00:32.227 and with that I would like to thank you for joining us and thank you! 01:00:32.394 --> 01:00:35.411 both Radhika and David for your great presentation here 01:00:35.830 --> 01:00:39.182 on the topic of scaling up for medtech innovation with 3D printing. 01:00:39.727 --> 01:00:43.330 So thank you and have a good rest of the day wherever you are 01:00:43.917 --> 01:00:44.545 Bye.